Okaramine C, a New Insecticidal Indole Alkaloid fromPenicillium simplicissimum
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چکیده
منابع مشابه
GluCl a target of indole alkaloid okaramines: a 25 year enigma solved
In 1989, indole alkaloid okaramines isolated from the fermentation products of Penicillium simplicissimum were shown to be insecticidal, yet the mechanism of their toxicity to insects remains unknown. We therefore examined the action of okaramine B on silkworm larval neurons using patch-clamp electrophysiology. Okaramine B induced inward currents which reversed close to the chloride equilibrium...
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Four new okaramine congeners, okaramines J, K, L and M, were isolated from okara fermented with Penicillium simplicissimum ATCC 90288, together with five biogenetically related compounds, cyclo (8a-(α,α-dimethylallyl)-L-Trp-8a-(α,α-dimethylallyl)-L-Trp), cyclo (N (8)-(α,α-dimethylallyl)-L-Trp-6a'-(α,α-dimethylallyl)-L-Trp), cyclo (L-Trp-L-Trp), cyclo (6a'-(α,α-dimethylallyl)-L-Trp-L-Trp), and c...
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A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey's method applied to its...
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Um novo alcalóide, denominado histrixnina (1), e cinco alcalóides indólicos conhecidos, ibogamina (2), olivacina (3) e affinina (4), affinisina (5) e N b -metilaffinisina (6), foram isolados do extrato metanólico das cascas das raízes de Tabernaemontana hystrix. Os triterpenos conhecidos 3O-acetil-α-amirina, 3-O-acetil-β-amirina, 3-O-acetil-lupeol foram também identificados. As estruturas dos c...
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Indole alkaloids are well characterized for diverse activities. Meanwhile, the present scenario of disease depicting a different story, urge a call for novel scaffolds and pharmacophores. In recent years, indole based alkaloids gain significant importance in cancer chemotherapy and used as an adjuvant especially in case of Vinca alkaloids. These reports encourage the researchers for new finding...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1991
ISSN: 0002-1369
DOI: 10.1080/00021369.1991.10857916